Key result
Nitric oxide donors SNAP and SNP inhibited the noradrenaline-evoked rise in global intracellular Ca2+ by a cGMP-independent mechanism, partly by inhibiting the activity of frequent discharge sites.
Population
Single myocytes freshly isolated from small mesenteric arteries of guinea-pig
Comparison
Nitric oxide donors S-nitroso-N-acetylpenicillami… vs Resting state / absence of NO donors
Design
Preclinical
Authors
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No immediate clinical implications; leaves open translation of cGMP-independent calcium regulation to human vascular disease.
Nitric oxide donors inhibit noradrenaline-induced intracellular calcium increases in smooth muscle cells via a cGMP-independent reduction in calcium spark activity at specific release sites.
Pucovský et al. (2002) studied this question. Nitric oxide donors (SNAP and SNP) and noradrenaline vs. Resting state / absence of NO donors was evaluated on Position and activity of frequent discharge sites (FDSs) and global intracellular Ca2+ concentration. Nitric oxide donors SNAP and SNP inhibited the noradrenaline-evoked rise in global intracellular Ca2+ by a cGMP-independent mechanism, partly by inhibiting the activity of frequent discharge sites.
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