April 1, 1997AJP Lung Cellular and Molecular Physiology

Role of ryanodine receptor channels in Ca2+ oscillations of porcine tracheal smooth muscle

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Population

Porcine tracheal smooth muscle (TSM) cells (beta-escin permeabilized)

Design

Preclinical

Authors

MKMathur KannanHomi Bhabha National Institute YPY. S. PrakashMayo Clinic TBTalma BrennerHadassah Medical Center

Discussion

Member takes

Implication

RyR role in porcine tracheal Ca2+ oscillations; leaves open translation to human airway disease or therapies.

Structured PICO

Population

Porcine tracheal smooth muscle (TSM) cells (beta-escin permeabilized)

Intervention

Exposure to acetylcholine (ACh), IP3, heparin (IP3 receptor antagonist), or ruthenium red (RyR antagonist)

Outcome

Intracellular Ca2+ concentration ([Ca2+]i) oscillationssurrogate

Sarcoplasmic reticulum Ca2+ release through ryanodine receptor channels is critical for acetylcholine-induced Ca2+ oscillations in porcine tracheal smooth muscle cells.

Cite This Study

Kannan et al. (1997) studied this question.

synapsesocial.com/papers/6a8c45797220baec05bbba08 https://doi.org/10.1152/ajplung.1997.272.4.l659

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Role of ryanodine receptor channels in Ca2+ oscillations of porcine tracheal smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of ryanodine receptor channels in Ca2+ oscillations of porcine tracheal smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider