Key result
In porcine tracheal smooth muscle cells, intracellular and intercellular heterogeneity in calcium levels reflects heterogeneities in calcium regulatory mechanisms.
Population
Porcine tracheal smooth muscle (TSM) cells and bronchial cells
Design
Preclinical
Authors
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Should not change clinical practice; hypothesis-generating for calcium heterogeneity in human airway smooth muscle.
Intracellular and intercellular heterogeneity in calcium levels in airway smooth muscle reflects heterogeneities in calcium regulatory mechanisms.
Sieck et al. (1997) studied this question. Acetylcholine, ryanodine, and caffeine was evaluated on Intracellular Ca2+ sparks and oscillations. In porcine tracheal smooth muscle cells, intracellular and intercellular heterogeneity in calcium levels reflects heterogeneities in calcium regulatory mechanisms.