Why the study?
Does polymerase chain reaction accurately detect the measles virus sequence in clinical samples from patients with measles?
Population
32 patients with measles, 2 patients with modified courses of measles, and negative controls without…
Comparison
Polymerase chain reaction to detect measles… vs Negative controls without apparent measles…
Design
Case-control
Authors
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Supports PCR for measles detection in clinical samples; leaves open prospective validation before diagnostic adoption.
Does polymerase chain reaction accurately detect the measles virus sequence in clinical samples from patients with measles?
Polymerase chain reaction is a sensitive and specific method for detecting measles virus in clinical samples, including early detection in cerebrospinal fluid during central nervous system involvement.
Yoshihiro Matsuzono (1994) studied this question.
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