May 1, 1996Journal of the American Society of Nephrology

Angiotensin II modulates glomerular capillary permselectivity in rat isolated perfused kidney.

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Why the study?

Does Angiotensin II infusion increase glomerular capillary permeability to macromolecules in isolated perfused rat kidneys?

Population

Isolated perfused rat kidney preparation

Comparison

Continuous Angiotensin II infusion into the… vs Basal values

Design

Preclinical

Authors

RŁRadosław ŁapińskiMedical University of Białystok NPNorberto PericoMario Negri Institute for Pharmacological Research ARAndrea RemuzziUniversity of Bergamo

Discussion

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Implication

Supports AT1-mediated permeability mechanism in rat models; leaves open translation to human proteinuric disease.

Structured PICO

Does Angiotensin II infusion increase glomerular capillary permeability to macromolecules in isolated perfused rat kidneys?

Population

Isolated perfused rat kidney preparation

Intervention

Continuous Angiotensin II (AII) infusion into the renal artery at 0.6, 3, or 8 ng/min, with or without pretreatment with AII Type 1 receptor antagonist SR 47436

Comparator

Basal values

Outcome

Urinary protein excretion rate and fractional clearance of polydisperse Ficollsurrogate

Angiotensin II directly increases glomerular permeability to macromolecules via the AT1 receptor, providing a mechanism for the antiproteinuric effects of renin-angiotensin system inhibitors.

Cite This Study

Łapiński et al. (1996) studied this question.

synapsesocial.com/papers/6a8c4cc7ce55b7ff59bd58ce https://doi.org/10.1681/asn.v75653

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Angiotensin II modulates glomerular capillary permselectivity in rat isolated perfused kidney.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II modulates glomerular capillary permselectivity in rat isolated perfused kidney.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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