Profiling of proatherogenic and atheroprotective biomarkers in asymptomatic severe carotid atherosclerosis may aid in early diagnosis and individual risk prognosis.
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May inform risk prognosis in asymptomatic carotid atherosclerosis; hypothesis-generating correlations require prospective validation.
The article deals with the results of a study of “asymptomatic” patients with severe stenosing process in the brachiocephalic arteries (as a model of carotid atherosclerosis), with emphasis on the determination of biochemical markers associated with various stages of atherogenesis. The definition of a group of proatherogenic and atheroprotective biomarkers is suggested and substantiated. The article describes correlations among biomarkers that have a potential etiopathogenic nature, which necessitates further validation of these pathological changes in larger groups of patients.
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Tanashyan et al. (2016) studied this question.
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