Why the study?
Subarachnoid haemorrhage causes sudden cardiac death, but the time course of ventricular arrhythmias and the potential mechanisms responsible after subarachnoid haemorrhage remain unknown.
Does subarachnoid haemorrhage induce transient ventricular electrophysiological changes and increase susceptibility to ventricular arrhythmias in a rat model?
Population
Sprague Dawley rat model of SAH
Comparison
Post-SAH at Days 1, 3, 7, 14, and 28 vs baseline
Design
Preclinical animal model study
Follow-up
28 days
Authors
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Transient QTc prolongation and reduced VFT peak acutely post-SAH in rats; leaves open human translation for arrhythmia monitoring.
Does subarachnoid haemorrhage induce transient ventricular electrophysiological changes and increase susceptibility to ventricular arrhythmias in a rat model?
Subarachnoid haemorrhage causes transient acute-phase ventricular electrophysiological changes and increased arrhythmia susceptibility mediated by sympathetic overactivity in a rat model.
Chen et al. (2023) studied this question.
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