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March 8, 2010American Journal of Medical Genetics Part B Neuropsychiatric Genetics

BDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects

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Why the study?

Does the BDNF Val66Met polymorphism alter sympathovagal balance in healthy adults?

Population

211 healthy Chinese-Han adults (58 male, 153 female, aged 33.3 +/- 10.3 years)

Comparison

BDNF Val66Met polymorphism (Met/Met genotype) vs Val/Val genotype

Design

Cross-sectional

Authors

AYAlbert C. YangTCTai‐Jui ChenSTShih‐Jen Tsai

Discussion

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Overview

Met/Met genotype was associated with reduced parasympathetic tone; hypothesis-generating for BDNF Val66Met effects on autonomic balance.

Structured PICO

Does the BDNF Val66Met polymorphism alter sympathovagal balance in healthy adults?

P
Population
211 healthy Chinese-Han adults (58 male, 153 female, aged 33.3 +/- 10.3 years)
I
Intervention
BDNF Val66Met polymorphism (Met/Met genotype)
C
Comparator
Val/Val genotype
O
Outcome
Autonomic function assessed via heart rate variability (high-frequency power and low-frequency/high-frequency ratio)surrogate

The BDNF Val66Met polymorphism (Met/Met genotype) is associated with altered sympathovagal balance and decreased parasympathetic activity in healthy adults.

Cite This Study

Yang et al. (2010) studied this question.

synapsesocial.com/papers/6a8c88fd4041bb0c0f4e0960https://doi.org/10.1002/ajmg.b.31069
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Also Consider

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  1. 1Limbic dysregulation is associated with lowered heart rate variability and increased trait anxiety in healthy adults2007 · 93 citations
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  3. 3Relationship of Heart Rate Variability to Parasympathetic Effect2001 · 330 citations
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  5. 5Meta-Analysis of the Brain-Derived Neurotrophic Factor Gene (BDNF) Val66Met Polymorphism in Anxiety Disorders and Anxiety-Related Personality Traits2008 · 139 citations