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December 24, 2015European Heart JournalOpen Access

BDNFVal66met polymorphism: a potential bridge between depression and thrombosis

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Population

Knock-in mice carrying the BDNFVal66Met human polymorphism, wild-type mice, WT cells, and human subjects.

Comparison

SIRT1 activation, SIRT1 inhibition, or… vs Wild-type mice, WT cells, or untreated controls.

Design

Preclinical

Authors

PAPatrizia AmadioGCGualtiero I. ColomboETEva Tarantino

Discussion

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Overview

Animal data on BDNFVal66Met link psychiatric traits to CVD; leaves open human translation and clinical relevance.

Structured PICO

P
Population
Knock-in mice carrying the BDNFVal66Met human polymorphism (BDNFMet/Met), wild-type (WT) mice, WT cells, and human subjects.
I
Intervention
SIRT1 activation (resveratrol and/or CAY10591), SIRT1 inhibition (sirtinol and/or specific siRNA), or transfection with BDNFMet construct.
C
Comparator
Wild-type (WT) mice, WT cells, or untreated controls.
O
Outcome
FeCl3-induced carotid artery thrombosis, death after collagen/epinephrine injection, and acute myocardial infarction (AMI) risk.surrogate

The BDNFVal66Met polymorphism, associated with depression, induces a prothrombotic state and increases AMI risk, providing a mechanistic link between psychiatric conditions and cardiovascular disease.

Cite This Study

Amadio et al. (2015) studied this question.

synapsesocial.com/papers/6a71a43735aa2c282ce2da4ehttps://doi.org/10.1093/eurheartj/ehv655
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Brain-derived neurotrophic factor Val66Met polymorphism in depression and thrombosis: SIRT1 as a possible mediator2015 · 13 citations
  2. 2The α2-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism2021 · 7 citations
  3. 3Impact of BDNF Val66Met Polymorphism on Myocardial Infarction: Exploring the Macrophage Phenotype2020 · 26 citations
  4. 4BDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects2010 · 57 citations
  5. 5Val66Met and Genetic Predisposition to Obesity, Mood, and Sleep Disorders2025