Population
Transgenic mouse embryos (CD-1) and cell culture models (C3H10T1/2 fibroblasts, C2C12 myoblasts and myotubes)
Comparison
HRC enhancer constructs fused to lacZ or CAT… vs Promoterless reporter constructs, mutant…
Design
Preclinical
Authors
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Advances knowledge of muscle-specific transcription; leaves open relevance to human cardiovascular disease or therapies.
The study identifies the HRC enhancer as the first MEF2-dependent, CArG-independent transcriptional target in smooth muscle, governing expression across cardiac, skeletal, and arterial smooth muscle lineages.
Anderson et al. (2004) studied this question.
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