Population
Susceptible chicken embryos, day-old chickens, and primary cultures of chicken embryo brain cells
Comparison
Infection with field strain, vaccine strain, or… vs Comparison between the different viral strains
Design
Preclinical
Authors
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Strain-specific tropism may guide avian vaccine selection; hypothesis-generating for picornavirus tissue preference mechanisms.
Different strains of avian encephalomyelitis virus exhibit distinct tissue tropisms (neurotropic vs enterotropic) despite similar structural viral proteins.
Shafren et al. (1991) studied this question.
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