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February 1, 1978Australian Veterinary Journal

The Pathogenesis of Infectious Avian Encephalomyelitis

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Why the study?

Does age at infection or testosterone treatment affect the pathogenesis of infectious avian encephalomyelitis in chickens?

Population

Chickens (varying ages, some treated with testosterone in ova)

Comparison

Infection with infectious avian… vs Chickens of different ages; untreated chickens

Design

Preclinical

Authors

HWH. A. WestburyUniversity of Technology SydneyBSB. SinkovicThe University of Sydney

Discussion

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Overview

Testosterone abolishes age-related IAEV resistance in chickens via delayed antibodies; hypothesis-generating for hormonal modulation of antiviral immunity.

Structured PICO

Does age at infection or testosterone treatment affect the pathogenesis of infectious avian encephalomyelitis in chickens?

P
Population
Chickens (varying ages, some treated with testosterone in ova)
I
Intervention
Infection with infectious avian encephalomyelitis virus (IAEV); testosterone treatment in ova
C
Comparator
Chickens of different ages; untreated chickens
O
Outcome
Development of clinical infectious avian encephalomyelitis (IAE), virus titre in the brain, duration of viraemia, and production of IAEV serum neutralising antibodysurrogate

The ability to produce IAEV serum neutralizing antibody is an important component of age-associated resistance to infectious avian encephalomyelitis in chickens.

Cite This Study

Westbury et al. (1978) studied this question.

synapsesocial.com/papers/6a97b810ce42e14121e1738chttps://doi.org/10.1111/j.1751-0813.1978.tb00350.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ecological Survey by the Immunofluorescent Method of Virus in Enzootics of Avian Encephalomyelitis1974 · 9 citations
  2. 2Mortality Patterns and Antibody Response in Chicks Inoculated with Eastern Equine Encephalomyelitis Virus1961 · 10 citations
  3. 3Pathogenesis of avian encephalomyelitis viruses1991 · 14 citations
  4. 4Avian encephalomyelitis: A review1994 · 46 citations
  5. 5Characterization of Avian Encephalomyelitis Outbreaks Occurred in South Korea from 2006 to 20132015