Key result
In chickens, EEE virus triggers hemagglutination-inhibiting antibodies before neutralizing antibodies, persisting at least 140 weeks.
Why the study?
The study aimed to characterize antibody response and mortality patterns in chickens experimentally infected with Eastern equine encephalomyelitis virus.
Population
Chickens experimentally infected with Eastern equine encephalomyelitis virus
Comparison
Age groups of chickens at infection (3rd to 14th day vs 14 days or older)
Design
Experimental infection study
Follow-up
At least 140 weeks
Authors
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Supports HI assay for early durable serology in avian EEEV; leaves open translation to other species or vaccines.
The HI test effectively detects early and persistent antibody responses in chickens infected with Eastern equine encephalomyelitis virus, with resistance to mortality increasing with age.
Byrne et al. (1961) studied Eastern equine encephalomyelitis virus infection. Eastern equine encephalomyelitis virus infection was evaluated on Hemagglutination-inhibiting antibody detection and mortality. In chickens experimentally infected with Eastern equine encephalomyelitis virus, hemagglutination-inhibiting antibody is detectable prior to neutralizing antibody and persists for at least 140 weeks.
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