Why the study?
To investigate the effect of reduced inspired fraction of O2 on the correspondence between the respiratory compensation point and the NIRS-derived [HHb] breakpoint during a ramp-incremental test to exhaustion.
Does hypoxia alter the correspondence between the respiratory compensation point and the deoxygenated hemoglobin breakpoint during a ramp-incremental test in young active males?
Does hypoxia alter the correspondence between the respiratory compensation point and the deoxygenated hemoglobin breakpoint during a ramp-incremental test in young active males?
Breathing a lower FiO2 during a ramp-incremental test results in a proportional reduction in both the respiratory compensation point and the deoxygenated hemoglobin breakpoint, suggesting they reflect a common physiological phenomenon.
Answers are grounded in this paper and cite their sources.
Preserved RCP-[HHb]bp correspondence in hypoxia; hypothesis-generating for integrated thresholds beyond healthy males.
This study investigated the effect of reduced inspired fraction of O2 (FiO2) in the correspondence between the respiratory compensation point (RCP) and the breakpoint in the near-infrared spectroscopy-derived deoxygenated hemoglobin signal ([HHb]bp) during a ramp-incremental (RI) test to exhaustion. Eleven young males performed, on two separated occasions, a RI test either in normoxia (NORM, FiO2 = 20.9%) or hypoxia (HYPO, FiO2 = 16%). Oxygen uptake ( O2), and [HHb] signal from the vastus lateralis muscle were continuously measured. Peak O2 (2.98 ± 0.36 vs. 3.39 ± 0.26 L min−1) and PO (282 ± 29 vs. 310 ± 19 W) were lower in HYPO compared to NORM condition, respectively. The O2 and PO associated with RCP and [HHb]bp were lower in HYPO (2.35 ± 0.24 and 2.34 ± 0.26 L min−1; 198 ± 37 and 197 ± 30 W, respectively) when compared to NORM (2.75 ± 0.26 and 2.75 ± 0.28 L min−1; 244 ± 29 and 241 ± 28 W, respectively) (p < .05). Within the same condition, the O2 and PO associated with RCP and [HHb]bp were not different (p > .05). Bland–Altman plots mean average errors between RCP and [HHb]bp were not different from zero in HYPO (0.01 L min−1 and 1.1 W) and NORM (0.00 L min−1 and 3.6 W) conditions. The intra-individual changes between thresholds associated with O2 and PO in HYPO from NORM were strongly correlated (r = .626 and 0.752, p < .05). Therefore, breathing a lower FiO2 during a RI test resulted in proportional reduction in the RCP and the [HHb]bp in terms of O2 and PO, which further supports the notion that these physiological responses may arise from similar metabolic changes reflecting a common phenomenon.
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Azevedo et al. (2020) studied this question.
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