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June 1, 2020Physiological ReportsOpen Access

Hypoxia equally reduces the respiratory compensation point and the NIRS‐derived HHb breakpoint during a ramp‐incremental test in young active males

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Why the study?

To investigate the effect of reduced inspired fraction of O2 on the correspondence between the respiratory compensation point and the NIRS-derived [HHb] breakpoint during a ramp-incremental test to exhaustion.

Does hypoxia alter the correspondence between the respiratory compensation point and the deoxygenated hemoglobin breakpoint during a ramp-incremental test in young active males?

Population

Eleven young males

Comparison

Hypoxia (FiO2 = 16%) vs normoxia (FiO2 = 20.9%) during ramp-incremental exercise

Design

Crossover study with testing on two separate occasions

Authors

RARafael de Almeida AzevedoFundação Faculdade de MedicinaBEBéjar Saona J. E.University of CalgaryEIErin Calaine InglisUniversity of Verona

Discussion

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Overview

Preserved RCP-[HHb]bp correspondence in hypoxia; hypothesis-generating for integrated thresholds beyond healthy males.

Structured PICO

Does hypoxia alter the correspondence between the respiratory compensation point and the deoxygenated hemoglobin breakpoint during a ramp-incremental test in young active males?

P
Population
11 young active males
I
Intervention
Ramp-incremental (RI) test to exhaustion in hypoxia (FiO2 = 16%)
C
Comparator
Ramp-incremental (RI) test to exhaustion in normoxia (FiO2 = 20.9%)
O
Outcome
Correspondence between the respiratory compensation point (RCP) and the breakpoint in the near-infrared spectroscopy-derived deoxygenated hemoglobin signal ([HHb]bp)surrogate

Breathing a lower FiO2 during a ramp-incremental test results in a proportional reduction in both the respiratory compensation point and the deoxygenated hemoglobin breakpoint, suggesting they reflect a common physiological phenomenon.

Cite This Study

Azevedo et al. (2020) studied this question.

synapsesocial.com/papers/6a8cec9c634cd4ed83301be6https://doi.org/10.14814/phy2.14478
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