Population
Urethane-anaesthetized rats (vasopressinergic neurons in the supraoptic nucleus)
Comparison
Intracerebroventricular injection of Angiotensin… vs Basal firing rate or Ang II alone
Design
Preclinical
Follow-up
4-6 min
Authors
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Supports Ang III tonic control of vasopressin neuron firing in rodents; hypothesis-generating for human vasopressin regulation.
Endogenous Angiotensin III exerts tonic control on the basal firing level of vasopressinergic neurons, requiring conversion of Ang II to Ang III.
Zini et al. (1998) studied this question.
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