June 10, 2011American Journal of TransplantationOpen Access

Very Late Heart Transplant Rejection Is Associated with Microvascular Injury, Complement Deposition and Progression to Cardiac Allograft Vasculopathy

View Full Paper

Ask AI

Bookmark

Why the study?

Does very late rejection (VLR) increase the risk of cardiac allograft vasculopathy progression in clinically stable heart transplant recipients?

Population

196 clinically stable heart transplant recipients with >7-year follow-up (out of 398 consecutive recipients)

Comparison

Very late rejection vs Matched control group of patients without…

Design

Cohort

Follow-up

6.4 ± 1 years post-reference EMB

Authors

ALAlexandre LoupyDélégation Paris 5 ACAurélie CazesUniversité Paris Cité RGR. GuillemainAssistance Publique – Hôpitaux de Paris

Discussion

Member takes

Implication

Supports enhanced CAV surveillance after VLR; leaves open whether targeted interventions alter progression or survival in heart transplant recipients.

Structured PICO

Does very late rejection (VLR) increase the risk of cardiac allograft vasculopathy progression in clinically stable heart transplant recipients?

Population

196 clinically stable heart transplant recipients with >7-year follow-up (out of 398 consecutive recipients)

Intervention

Very late rejection (VLR, defined as subclinical ≥3A/2R-ISHLT rejection after 7 years post-transplant)

Comparator

Matched control group of patients without rejection

Outcome

Progression to cardiac allograft vasculopathy (CAV grade) and patient survivalsurrogate

Very late rejection in heart transplant recipients is frequently associated with antibody-mediated microvascular injury and leads to severe progression of cardiac allograft vasculopathy.

Cite This Study

Loupy et al. (2011) studied this question.

synapsesocial.com/papers/6a8cf6163022f0548e71bcb3 https://doi.org/10.1111/j.1600-6143.2011.03563.x

Topics

Heart transplantation

View Full Paper

Ask AI

Bookmark

Implication

Supports enhanced CAV surveillance after VLR; leaves open whether targeted interventions alter progression or survival in heart transplant recipients.

Very Late Heart Transplant Rejection Is Associated with Microvascular Injury, Complement Deposition and Progression to Cardiac Allograft Vasculopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Very Late Heart Transplant Rejection Is Associated with Microvascular Injury, Complement Deposition and Progression to Cardiac Allograft Vasculopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider