Why the study?
Is antibody-mediated rejection associated with late heart allograft failure and coronary arteriosclerosis in patients undergoing retransplantation?
Population
40 patients undergoing retransplantation for late terminal heart allograft failure across three referral…
Comparison
Assessment of explanted heart allografts for… vs Explanted allografts without evidence of…
Design
Cohort
Authors
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Highlights potential antibody-mediated injury in late allograft failure; leaves open targeted interventions pending prospective validation.
Is antibody-mediated rejection associated with late heart allograft failure and coronary arteriosclerosis in patients undergoing retransplantation?
Antibody-mediated rejection is present in a substantial fraction of late failing heart allografts and is significantly associated with severe coronary arteriosclerosis and microvascular inflammation.
Loupy et al. (2015) studied this question.
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