Why the study?
Studies evaluating the NOS1AP rs10494366 genetic polymorphism in modulating the QT interval and sudden cardiac death in general populations have yielded inconsistent conclusions.
Does the rs10494366 polymorphism in the NOS1AP gene correlate with the QT interval and sudden cardiac death in general populations?
Does the rs10494366 polymorphism in the NOS1AP gene correlate with the QT interval and sudden cardiac death in general populations?
The minor allele of rs10494366 in the NOS1AP gene is associated with QT interval modulation in women and diabetic patients, and with sudden cardiac death in Caucasian populations.
May warrant genotype-informed QT monitoring in women and diabetics; extends NOS1AP variant evidence for sudden death risk in Caucasians.
Contemporary studies have identified rs10494366 in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene as a new genetic marker in modulating the QT interval and sudden cardiac death (SCD) in general populations. However, the conclusions were not coincident. Therefore, we conducted for the first time a system evaluation of the relativity of rs10494366, the QT interval, and sudden death by meta-analysis. In our study, the meta-analysis displayed the GG genotype of rs10494366 correlated with the QT interval in women with no heterogeneity, and in diabetes mellitus (DM) patients with minor heterogeneity. In the Caucasian population, the correlation of rs10494366 and sudden death was significant. The heterogeneity referred to the relevance between rs10494366 and sudden death in the Asian population. In conclusion, the minor allele of rs10494366 may have an impact on the QT interval in women or DM patients and may have a potential role in sudden death in the Caucasian population.
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Zang et al. (2019) studied this question.
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