What question did this study set out to answer?

To identify clinical characteristics of Kawasaki disease in children aged 6 years and older and evaluate age as a risk factor for cardiovascular abnormalities.

September 1, 2004PEDIATRICS

Older Age Is a Risk Factor for the Development of Cardiovascular Sequelae in Kawasaki Disease

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Why the study?

Is older age (≥6 years) a risk factor for cardiovascular sequelae in children with Kawasaki disease compared to younger age (6 months to 3 years)?

Key Points

To identify clinical characteristics of Kawasaki disease in children aged 6 years and older and evaluate age as a risk factor for cardiovascular abnormalities.
Analyzed data from the 16th nationwide survey of Kawasaki disease in Japan conducted between 1999 and 2000 (total survey n=15,314).
Matched patients aged 6 years or older with control patients aged 6 months to 3 years treated at the same hospital, evaluating 1,498 total patients (749 matched pairs).
Patients aged ≥6 years experienced higher recurrence rates (9% vs 2%) and a higher prevalence of cardiovascular abnormalities (20% vs 15%) compared to younger controls.
The older group had lower overall intravenous gamma-globulin uptake (82% vs 87%) and a higher rate of delayed treatment initiated at or after day 7 of illness (35% vs 14%).
Multivariate logistic regression identified older age as an independent risk factor for cardiovascular sequelae (OR: 1.58; 95% CI: 1.01–2.46).

Structured PICO

Is older age (≥6 years) a risk factor for cardiovascular sequelae in children with Kawasaki disease compared to younger age (6 months to 3 years)?

Population

1,498 children with Kawasaki disease (749 matched pairs) from the 16th nationwide survey of KD in Japan (1999-2000).

Intervention

Older age (≥6 years)

Comparator

Younger age (6 months to 3 years)

Outcome

Cardiovascular abnormalities/sequelaehard clinical

Children older than 6 years with Kawasaki disease have a significantly higher risk of developing cardiovascular sequelae compared to younger children, highlighting the need for timely diagnosis and treatment in this age group.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports age-stratified risk assessment in Kawasaki disease; leaves open whether targeted strategies improve outcomes.

Cite This Study

Muta et al. (2004) studied this question.

synapsesocial.com/papers/6a8cfbb090796a61fcc6642a https://doi.org/10.1542/peds.2003-0118-f

Topics

Women and heart disease

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Older Age Is a Risk Factor for the Development of Cardiovascular Sequelae in Kawasaki Disease

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Older Age Is a Risk Factor for the Development of Cardiovascular Sequelae in Kawasaki Disease

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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Topics

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