Population
Chloralose-anesthetized, paralyzed, artificially respired, male Sprague-Dawley rats
Comparison
Spinal transection and localized lesions of the… vs Pretransection levels
Design
Preclinical
Authors
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Autoregulation may preserve renal vascular resistance but not excretory function after spinal injury; hypothesis-generating for autonomic renal effects in humans.
In a rat model, spinal transection increases renal sympathetic activity, but autoregulation maintains renal vascular resistance, while changes in renal function depend on both arterial pressure and sympathetic activity.
Osborn et al. (1987) studied this question.
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