What question did this study set out to answer?

To identify the clinical causes and biological markers that predict one-year hospital readmissions in patients aged 65 years or older hospitalized with heart failure with preserved ejection fraction.

June 1, 2015Clinical Interventions in AgingOpen Access

Causes and predictors of hospital readmissions in patients older than 65 years hospitalized for heart failure with preserved left ventricular ejection fraction in western Romania

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Population

178 consecutive patients hospitalized for a first heart failure episode with preserved ejection fraction…

Design

Cohort

Follow-up

1-year

Authors

MTMirela TomescuVictor Babeș University of Medicine and Pharmacy Timișoara AMAdelina MavreaVictor Babeș University of Medicine and Pharmacy Timișoara TDT DragomirVictor Babeș University of Medicine and Pharmacy Timișoara

Discussion

Member takes

Implication

May warrant enhanced surveillance for HF aggravation in elderly HFpEF; leaves open whether biomarker thresholds can guide preventive strategies.

Key Points

To identify the clinical causes and biological markers that predict one-year hospital readmissions in patients aged 65 years or older hospitalized with heart failure with preserved ejection fraction.
Prospective cohort study of consecutive patients (N=178) hospitalized for a first heart failure episode, stratified into elderly (≥65 years, n=98) and nonelderly (<65 years, n=80) cohorts with 1-year follow-up.
Assessed clinical outcomes and therapeutic approaches, and performed multivariate logistic regression to identify independent clinical and biological predictors of readmission.
Elderly patients experienced significantly higher overall 1-year readmission rates (73% vs 55%, P<0.02) and higher readmission rates due to aggravated heart failure (41% vs 18%, P<0.002) compared to nonelderly patients.
In elderly patients, readmission due to heart failure aggravation was independently predicted by brain natriuretic peptide >450 pg/mL (P<0.01) and N-terminal-pro-brain natriuretic peptide >477 pg/mL (P<0.02).
Readmission due to noncardiovascular causes was independently predicted by tumor necrosis factor-alpha >10 pg/mL in elderly patients (P=0.003) and interleukin-6 >1.9 pg/mL in nonelderly patients (P<0.04).

Structured PICO

Population

178 consecutive patients hospitalized for a first heart failure episode with preserved ejection fraction (HFpEF), mean age 64.6±8.6 years, 45% women, in western Romania.

Outcome

Hospital readmissions (causes and predictors) during 1-year follow-uphard clinical

In patients with HFpEF, being aged ≥65 years is associated with higher 1-year readmission rates, primarily driven by HF aggravation and predicted by elevated natriuretic peptides.

Cite This Study

Tomescu et al. (2015) studied this question.

synapsesocial.com/papers/6a8cfefdcf4f1803a62f05c3 https://doi.org/10.2147/cia.s83750

Topics

Heart failure HFrEF treatment Heart failure hospitalization HFpEF management

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Implication

May warrant enhanced surveillance for HF aggravation in elderly HFpEF; leaves open whether biomarker thresholds can guide preventive strategies.

Causes and predictors of hospital readmissions in patients older than 65 years hospitalized for heart failure with preserved left ventricular ejection fraction in western Romania

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Causes and predictors of hospital readmissions in patients older than 65 years hospitalized for heart failure with preserved left ventricular ejection fraction in western Romania

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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