What question did this study set out to answer?

To determine how coronary microvascular function, glucose metabolism, and body composition influence exercise capacity in overweight, non-diabetic patients with coronary artery disease.

November 26, 2015BMC Cardiovascular DisordersOpen Access

Coronary microvascular function, insulin sensitivity and body composition in predicting exercise capacity in overweight patients with coronary artery disease

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Why the study?

What are the predictors of exercise capacity in overweight patients with stable CAD and without diabetes?

Key Points

To determine how coronary microvascular function, glucose metabolism, and body composition influence exercise capacity in overweight, non-diabetic patients with coronary artery disease.
Assessed 65 non-diabetic, overweight patients (BMI 28–40 kg/m², LVEF > 35%) with stable coronary artery disease.
Evaluated peak aerobic capacity (VO2peak) via cardiopulmonary exercise testing, coronary flow reserve (CFR) via Doppler echocardiography, glucose metabolism via 3-hour OGTT, and body composition via DXA and MRI.
VO2peak adjusted for fat-free mass significantly correlated with CFR (r = 0.41, p = 0.0007), LVEF (r = 0.33, p = 0.008), and left ventricular end-diastolic volume (r = 0.32, p = 0.01).
Multivariable regression identified CFR, end-diastolic volume, and LVEF as independent predictors of VO2peak, while body composition and glucose metabolism parameters had only weak, minor effects.

Structured PICO

What are the predictors of exercise capacity in overweight patients with stable CAD and without diabetes?

Population

65 non-diabetic, overweight patients with stable CAD, BMI 28-40 kg/m2, and LVEF > 35%

Outcome

Peak aerobic exercise capacity (VO2peak) assessed by cardiopulmonary exercise testsurrogate

Central hemodynamic factors, including coronary flow reserve and LVEF, are independent predictors of exercise capacity in overweight non-diabetic CAD patients, whereas glucose metabolism and body composition have minor impact.

Discussion

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Implication

CFR and LVEF may influence exercise capacity more than metabolism in overweight non-diabetic CAD; leaves open causal validation and intervention trials.

Cite This Study

Jürs et al. (2015) studied this question.

synapsesocial.com/papers/6a8d01fbb172e84f73c66430 https://doi.org/10.1186/s12872-015-0151-9

Topics

Coronary artery disease Coronary CT angiography

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Implication

CFR and LVEF may influence exercise capacity more than metabolism in overweight non-diabetic CAD; leaves open causal validation and intervention trials.

Coronary microvascular function, insulin sensitivity and body composition in predicting exercise capacity in overweight patients with coronary artery disease

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Coronary microvascular function, insulin sensitivity and body composition in predicting exercise capacity in overweight patients with coronary artery disease

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider