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October 1, 1952CirculationOpen Access

Histogenesis of Coronary Arteriosclerosis

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Authors

HMHenry D. MoonUniversity of the PacificJRJames F. RinehartArthritis Foundation

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Implication

Autopsy study reveals progressive structural stages of coronary arteriosclerosis across age groups, suggesting that vessel wall remodeling precedes lipid deposition.

Key Points

  • To investigate the histopathologic processes and structural sequence underlying the initiation and progression of coronary arteriosclerosis across human lifespans.
  • Examined coronary arteries collected postmortem from individuals dying suddenly from traumatic or natural causes (N=250).
  • Evaluated histological sections from infants through adults to characterize cellular and structural alterations at varying disease stages.
  • Earliest structural changes appeared in infants, marked by increased fibroblastic activity, mucopolysaccharide deposition, and elastic tissue degeneration independent of lipid accumulation.
  • Moderately advanced lesions developed through elastic tissue regeneration, collagen synthesis, and initial lipid deposition.
  • Far-advanced lesions exhibited severe arterial wall remodeling characterized by hyalinization, extensive lipid accumulation, calcification, intramural hemorrhage, and thrombosis.

Cite This Study

Moon et al. (1952) studied this question.

synapsesocial.com/papers/6a8d0442d8903deb3bd4f866https://doi.org/10.1161/01.cir.6.4.481
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Also Consider

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  1. 1HYPERPLASTIC ARTERIOSCLEROSIS VERSUS ATHEROSCLEROSIS1950 · 34 citations
  2. 2THE PREDILECTION OF ATHEROSCLEROSIS FOR THE CORONARY ARTERIES1946 · 159 citations