Why the study?
Myocardial hypertrophy increases propensity to malignant arrhythmias whereas they are rare in conditions associated with myocardial atrophy, possibly influenced by the gap junction protein connexin-43.
Does myocardial hypertrophy or atrophy alter connexin-43 expression and topology in rat models?
Does myocardial hypertrophy or atrophy alter connexin-43 expression and topology in rat models?
Differences in cardiac Cx43 abundance and topology may partly explain the distinct propensity of hypertrophied versus atrophied hearts to malignant arrhythmias.
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Should not alter clinical arrhythmia management; leaves open the mechanistic role of connexin-.
Bačová et al. (2023) studied this question.
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