February 5, 2009American Journal of HypertensionOpen Access

Steroid Biosynthesis and Renal Excretion in Human Essential Hypertension: Association With Blood Pressure and Endogenous Ouabain

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Population

729 untreated patients with essential hypertension

Design

Cross-sectional

Authors

GTGrazia TripodiUniversity of Mary LCLorena CitterioVita-Salute San Raffaele University TKTatiana KouznetsovaInstitute of General and Inorganic Chemistry of National Academy of Sciences of Belarus

Discussion

Member takes

Implication

EO-DBP association in essential hypertension is hypothesis-generating; leaves open causal role of CYP11A1/MDR1 variants and any therapeutic implications.

Structured PICO

Population

729 untreated patients with essential hypertension

Outcome

Association of endogenous ouabain (EO) levels and genetic variants (CYP11A1, HSD3B1, MDR1) with 24-hour ambulatory blood pressuresurrogate

Genetic variants in cholesterol side-chain cleavage (CYP11A1) and transmembrane transport (MDR1) are associated with circulating endogenous ouabain and diastolic blood pressure in essential hypertension.

Cite This Study

Tripodi et al. (2009) studied this question.

synapsesocial.com/papers/6a8d18bfb6a5e72a852fe3d8 https://doi.org/10.1038/ajh.2009.3

Topics

Hypertension management

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Implication

EO-DBP association in essential hypertension is hypothesis-generating; leaves open causal role of CYP11A1/MDR1 variants and any therapeutic implications.

Steroid Biosynthesis and Renal Excretion in Human Essential Hypertension: Association With Blood Pressure and Endogenous Ouabain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Steroid Biosynthesis and Renal Excretion in Human Essential Hypertension: Association With Blood Pressure and Endogenous Ouabain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider