Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1962Acta Physiologica Scandinavica

Studies on the Effects of Drugs upon the Lactic Acid Metabolism and Contraction of Vascular Smooth Muscle

View Full Paper
Ask AI
Bookmark
Share

Population

Bovine mesenteric arteries

Design

Preclinical

Authors

LLLennart LundholmLinköping UniversityEMElla Mohme‐LundholmLinköping University

Discussion

Loading...

Member takes

Implication

Animal data suggest glycolytic dependence in contraction; leaves open whether oxygen consumption alone indicates energy use in research or clinic.

Structured PICO

P
Population
Bovine mesenteric arteries
I
Intervention
Contracting drugs (adrenaline, noradrenaline, histamine, Ba++-ions) and electrical stimulation
O
Outcome
Lactic acid production and muscle contractionsurrogate

Vascular smooth muscle contraction is highly dependent on continuous energy production (glycolysis), and oxygen consumption alone is not a reliable indicator of its energy metabolism.

Cite This Study

Lundholm et al. (1962) studied this question.

synapsesocial.com/papers/6a8d1904b27309dd08099f3ahttps://doi.org/10.1111/j.1748-1716.1962.tb02418.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE DETERMINATION OF LACTIC ACID1929 · 278 citations
  2. 2The Rate of Respiration and Glycolysis by Human and Dog Aortic Tissue1954 · 82 citations
  3. 3The heat of shortening and the dynamic constants of muscle1938 · 5,626 citations