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January 1, 1976Japanese Circulation Journal-english EditionOpen Access

Plasma Catecholamine Levels in the Coronary Sinus, Aorta and Femoral Vein of Subjects Undergoing Cardiac Catheterization at Rest and During Exercise.

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Why the study?

Does handgrip exercise alter plasma catecholamine levels in the coronary sinus, aorta, and femoral vein compared to rest in patients undergoing cardiac catheterization?

Population

22 patients with various heart diseases undergoing cardiac catheterization

Comparison

Handgrip exercise (IHG) vs Rest

Design

Cross-sectional

Authors

YMYukio MiuraApple (Israel)THTakashi HanedaHyogo Medical UniversityTSTatsuo SatoNihon University

Discussion

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Implication

Handgrip exercise may raise norepinephrine during catheterization; supports direct coronary sinus sampling for sympathetic assessment but remains hypothesis-generating.

Key Points

  • To determine regional plasma catecholamine levels across the coronary and peripheral circulation at rest and during isometric exercise to evaluate cardiac sympathetic contribution.
  • Simultaneous blood sampling from the coronary sinus, aorta, and femoral vein in 22 patients with various heart diseases undergoing cardiac catheterization.
  • Plasma norepinephrine and epinephrine levels measured under resting conditions and during isometric handgrip exercise.
  • Resting aortic epinephrine was significantly higher (186 ± 30 pg/ml) than levels in the coronary sinus (127 ± 18 pg/ml) and femoral vein (97 ± 11 pg/ml; p < 0.05).
  • Handgrip exercise increased norepinephrine by 81% in the coronary sinus, 54% in the aorta, and 67% in the femoral vein, with epinephrine increasing by 70% across all sampled sites.
  • Coronary sinus norepinephrine output accounted for only 3% of aortic output at rest and 5% during exercise, with net transcardiac increment remaining at 2% or less.

Structured PICO

Does handgrip exercise alter plasma catecholamine levels in the coronary sinus, aorta, and femoral vein compared to rest in patients undergoing cardiac catheterization?

P
Population
22 patients with various heart diseases undergoing cardiac catheterization
I
Intervention
Handgrip exercise (IHG)
C
Comparator
Rest
O
Outcome
Plasma catecholamine (norepinephrine and epinephrine) levels in the coronary sinus, aorta, and femoral veinsurrogate

Direct measurement of norepinephrine levels in the coronary sinus is necessary to study sympathetic nerve activity in cardiac function, as cardiac tissue is not a major source of circulating catecholamines.

Cite This Study

Miura et al. (1976) studied this question.

synapsesocial.com/papers/6a8d19fdd8903deb3bd4fd13https://doi.org/10.1253/jcj.40.929
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation between the response of the heart to sympathetic stimulation and the release of endogenous catecholamines into the coronary sinus of the dog.1975 · 149 citations
  2. 2The Relationship between Plasma Catecholamine Concentration and Pulse Rate during Exercise and Standing1973 · 128 citations
  3. 3Myocardial Extraction and Production of Catechol Amines1961 · 65 citations
  4. 4Biochemical Evaluation of Sympathetic Nerve Tone in Essential Hypertension1975 · 7 citations
  5. 5Plasma Norepinephrine Levels in Essential Hypertension1973 · 283 citations