Why the study?
Does local brachial artery infusion of L-NMMA and noradrenaline alter forearm blood flow differently in patients with decompensated versus compensated alcoholic cirrhosis?
Does local brachial artery infusion of L-NMMA and noradrenaline alter forearm blood flow differently in patients with decompensated versus compensated alcoholic cirrhosis?
The differential vasomotor responses to NO-synthase inhibition and noradrenaline suggest that increased vascular synthesis of nitric oxide contributes to the hyperdynamic state and peripheral vasodilation in advanced cirrhosis.
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Supports greater NO-mediated vasodilation in decompensated cirrhosis; hypothesis-generating for targeted interventions.
Campillo et al. (1995) studied this question.
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