February 1, 1987AJP Gastrointestinal and Liver Physiology
Hyperglucagonemia and hyperkinetic circulation after portocaval shunt in the rat
Key result
Portocaval shunt increases rat cardiac output by ~64% alongside generalized circulatory disturbances.
- P<0.001
- n=17
Why the study?
It was unclear whether increased portal venous inflow after portocaval shunt in rats results from selective splanchnic vasodilatation or generalized circulatory disturbance.
Population
17 rats (9 with portocaval shunt, 8 sham-operated controls)
Comparison
Portocaval shunt vs sham-operated controls
Design
Preclinical experimental study
Follow-up
2 weeks
Authors
Discussion
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Overview
Urges caution extrapolating rat shunt hemodynamics to patients; extends animal models of generalized hypercirculation but leaves open human relevance.
Structured PICO
P
Population
17 rats studied 2 weeks after portocaval shunt or sham surgery to evaluate circulatory disturbances and glucagon levels.
I
Intervention
Portocaval shunt (PCS) surgery
C
Comparator
Sham-operated controls
O
Outcome
Cardiac output (CO), portal venous inflow (PVI), hepatic artery flow (HAF), and plasma glucagon (GL)surrogate
Main Result
Absolute Event Rate: 46.2% vs 28.2%
p-value: p=<0.001
Portocaval shunt in rats leads to a generalized hyperkinetic circulation rather than selective splanchnic vasodilatation, which correlates with increased plasma glucagon levels.
Cite This Study
Kravetz et al. (1987) studied Portocaval shunt (n=17). Portocaval shunt (PCS) vs. Sham-operated controls was evaluated on Cardiac output (ml/min/100g) (p=<0.001). Portocaval shunt in rats significantly increased cardiac output (46.2 vs 28.2 ml/min/100g, P<0.001) and portal venous inflow as part of a generalized circulatory disturbance.