Key result
Portal hypertensive rats had significantly decreased systemic sensitivity to norepinephrine compared with normal controls (NE ED50 60 vs 25 micrograms; P<0.001).
Why the study?
Does hyperglucagonism reduce systemic vascular sensitivity to norepinephrine in portal hypertensive rats?
Population
Male Sprague-Dawley rats divided into three groups: portal hypertensive, normal controls, and…
Comparison
Infusions of increasing doses of norepinephrine… vs Normal control rats.
Design
Preclinical
Authors
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Reduced norepinephrine sensitivity in portal hypertensive rats supports hyperglucagonism's role in vasodilation; leaves open human relevance.
Does hyperglucagonism reduce systemic vascular sensitivity to norepinephrine in portal hypertensive rats?
Absolute Event Rate: 60% vs 25%
p-value: p=<0.001
Hyperglucagonism may play a key role in the pathogenesis of systemic vasodilation in portal hypertension by reducing systemic vascular sensitivity to norepinephrine.
Pizcueta et al. (1990) studied Portal hypertension. Portal hypertension vs. Normal controls was evaluated on Norepinephrine ED50 (dose causing 50% maximal increase in systemic vascular resistance) (p=<0.001). Portal hypertensive rats had significantly decreased systemic sensitivity to norepinephrine compared with normal controls (NE ED50 60 vs 25 micrograms; P<0.001).
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