Why the study?
Does early cirrhosis of the liver alter vascular reactivity to norepinephrine in rats?
Population
Rats with early cirrhosis of the liver (showing water and sodium retention but not ascites) and control rats
Comparison
Norepinephrine administration vs Control rats
Design
Preclinical
Authors
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Preserved norepinephrine responsiveness in early cirrhosis rat models; leaves open vascular mechanisms of hypotension in human disease.
Does early cirrhosis of the liver alter vascular reactivity to norepinephrine in rats?
In early experimental cirrhosis, the peripheral vascular bed maintains its ability to constrict in response to norepinephrine, suggesting circulatory abnormalities are not due to vascular smooth muscle refractoriness.
Villamediana et al. (1988) studied this question.
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