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August 1, 1996Liver International

Role of sympathetic cardiovascular tone in control of arterial pressure in rats with cirrhosis

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Why the study?

Does hexamethonium reduce arterial pressure more in rats with cirrhosis compared to normal rats or those with portal vein stenosis?

Population

Normal rats, rats with cirrhosis, and rats with portal vein stenosis

Comparison

Hexamethonium (0.05 to 3.2 mg.kg-1.min-1) vs Normal rats and rats with portal vein stenosis

Design

Preclinical

Authors

PKP KirstetterUniversité Paris CitéRMRichard MoreauUniversité Paris-SudTSThierry SoupisonCentre Hospitalier Universitaire Amiens-Picardie

Discussion

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Overview

Does not support clinical changes in cirrhosis management; leaves open sympathetic tone contributions in human portal hypertension.

Structured PICO

Does hexamethonium reduce arterial pressure more in rats with cirrhosis compared to normal rats or those with portal vein stenosis?

P
Population
Normal rats, rats with cirrhosis, and rats with portal vein stenosis
I
Intervention
Hexamethonium (0.05 to 3.2 mg.kg-1.min-1)
C
Comparator
Normal rats and rats with portal vein stenosis
O
Outcome
Arterial pressure response and changes in plasma norepinephrine concentrationssurrogate

Sympathetic cardiovascular tone plays a more critical role in maintaining arterial pressure in rats with cirrhosis than in normal rats or those with portal vein stenosis.

Cite This Study

Kirstetter et al. (1996) studied this question.

synapsesocial.com/papers/6a7d49e514bfcdf15b6e4ffahttps://doi.org/10.1111/j.1600-0676.1996.tb00740.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Noradrenaline and adrenaline concentrations in various vascular beds in patients with cirrhosis Relation to haemodynamics.1981 · 90 citations
  2. 2Increased Sympathetic Nervous Activity and the Effects of Its Inhibition with Clonidine in Alcoholic Cirrhosis1992 · 115 citations
  3. 3Relationship between plasma norepinephrine and sympathetic neural activity.1983 · 354 citations
  4. 4Sympathetic Nervous Activity and Renal and Systemic Hemodynamics in Cirrhosis: Plasma Norepinephrine Concentration, Hepatic Extraction, and Renal Release1982 · 179 citations
  5. 5Catecholamine measurements by high-performance liquid chromatography1984 · 132 citations