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January 1, 1985Scandinavian Journal of Gastroenterology

Circulating Noradrenaline and Central Haemodynamics in Patients with Cirrhosis

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Population

22 patients with cirrhosis and 17 controls

Design

Case-control

Authors

JHJens H. HenriksenStatens Serum InstitutHRHelmer Ring‐LarsenUniversity of CopenhagenNCNiels Juel ChristensenUniversity of Wisconsin–Madison

Discussion

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Implication

Elevated noradrenaline may limit cardiac output in cirrhosis; leaves open whether sympathetic modulation improves hemodynamics.

Structured PICO

P
Population
22 patients with cirrhosis and 17 controls
C
Comparator
17 controls
O
Outcome
Arterial plasma noradrenaline (NA) levels and cardiovascular haemodynamicssurrogate

In patients with cirrhosis, elevated circulating noradrenaline indicates enhanced sympathetic nervous activity that inversely correlates with cardiac performance, suggesting a compensatory mechanism for cardiovascular homeostasis.

Cite This Study

Henriksen et al. (1985) studied this question.

synapsesocial.com/papers/6a8a76109be9d02581bdb29ehttps://doi.org/10.3109/00365528509089274
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hand Blood Flow, Plasma Norepinephrine, and Central Hemodynamics in Myocardial Infarction1974 · 4 citations
  2. 2Enhanced sympathetic nervous activity after intravenous propranolol in ischaemic heart disease: plasma noradrenaline splanchnic blood flow and mixed venous oxygen saturation at rest and during exercise1978 · 71 citations
  3. 3Noradrenaline and adrenaline concentrations in various vascular beds in patients with cirrhosis Relation to haemodynamics.1981 · 90 citations
  4. 4Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced sympathetic nervous activity in patients with decompensated cirrhosis.1984 · 186 citations
  5. 5Role of the Splanchnic Bed in Extracting Circulating Adrenaline and Noradrenaline in Normal Subjects and in Patients with Cirrhosis of the Liver1984 · 26 citations