Why the study?
Is the increase in plasma noradrenaline in cirrhosis driven by increased sympathetic nervous system activity or impaired metabolism/clearance?
Population
Patients with cirrhosis and normal subjects. Kinetics study: n=14 cirrhosis with ascites, n=13 normal…
Comparison
Intravenous infusion of [3H]noradrenaline to… vs Normal healthy subjects and cirrhotic patients…
Design
Cross-sectional
Authors
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Sympathetic overdrive may precede ascites in cirrhosis; hypothesis-generating for prognostic and interventional studies.
Is the increase in plasma noradrenaline in cirrhosis driven by increased sympathetic nervous system activity or impaired metabolism/clearance?
The elevation of plasma noradrenaline in cirrhosis is due to increased sympathetic nervous system activity rather than impaired metabolism, and this increase precedes the development of ascites.
MacGilchrist et al. (1991) studied this question.
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