Why the study?
Does nitric oxide inhibition with Nω-nitro-L-arginine increase arterial pressure more in cirrhotic rats with ascites compared to control rats?
Population
57 conscious rats (30 with cirrhosis and ascites, 27 controls) across two protocols.
Comparison
Nω-nitro-L-arginine infusion at increasing doses. vs Conscious control rats receiving the same…
Design
Preclinical
Authors
Loading...
Enhanced NO inhibition sensitivity in cirrhotic rats supports vasodilatory hypothesis; leaves open human translation and clinical testing.
Does nitric oxide inhibition with Nω-nitro-L-arginine increase arterial pressure more in cirrhotic rats with ascites compared to control rats?
Cirrhotic rats with ascites show enhanced sensitivity to the pressor effect of nitric oxide inhibition, suggesting that increased systemic release of nitric oxide contributes to arterial hypotension in cirrhosis.
Clària et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: