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May 1, 1996British Journal of PharmacologyOpen Access

Vasoconstrictor responsiveness of the rat mesenteric arterial bed in cirrhosis

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Population

Constantly perfused mesenteric arterial beds isolated from cirrhotic rats, and from phenobarbitone-treated…

Comparison

Electrical field stimulation and administration… vs Phenobarbitone-treated and untreated age-matched…

Design

Preclinical

Authors

VRVera RalevicUniversity of NottinghamRMRobert T. MathieHomeopathy Research InstituteKMKevin P. MooreThe Royal Free Hospital

Discussion

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Overview

Altered NO modulation of vasoconstriction in cirrhosis; leaves open relevance to human vascular dysfunction.

Structured PICO

P
Population
Constantly perfused mesenteric arterial beds isolated from cirrhotic rats (carbon tetrachloride with phenobarbitone, n = 6), and from phenobarbitone-treated (n = 4) and untreated (n = 5) age-matched controls.
I
Intervention
Electrical field stimulation (EFS) and administration of exogenous noradrenaline (NA), methoxamine, ATP, vasopressin, L-NAME, L-arginine, and glibenclamide at varying flow rates.
C
Comparator
Phenobarbitone-treated and untreated age-matched control rats.
O
Outcome
Changes in perfusion pressure (vasoconstrictor responsiveness) in response to electrical field stimulation and exogenous vasoactive agents.surrogate

Sympathetic neurotransmission remains unchanged in cirrhosis, but altered nitric oxide modulation may contribute to altered vascular responsiveness at higher flow rates.

Cite This Study

Ralevic et al. (1996) studied this question.

synapsesocial.com/papers/6a8d1d3e05d5ce98075be3f9https://doi.org/10.1111/j.1476-5381.1996.tb15421.x
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Also Consider

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  1. 1Release of endothelium derived nitric oxide in relation to pressure and flow1991 · 95 citations
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  5. 5In vitro hyporeactivity to methoxamine in portal hypertensive rats: reversal by nitric oxide blockade1992 · 110 citations