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August 1, 1995Hypertension

Kallikreins and Kinins

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Overview

No change to hypertension care; leaves open kallikrein-kinin modulation as a research target.

Key Points

  • To review emerging evidence on the functions of the kallikrein-kinin system in cellular homeostasis and its pathological relevance to human cardiovascular diseases, particularly hypertension.
  • Synthesized recent biomedical literature on kallikrein-kinin system characteristics and molecular cell behavior.
  • Evaluated physiological mechanisms and observational questions linking kinin pathway dysfunction to hypertensive disease.
  • The kallikrein-kinin system directly modulates diverse cellular activities and maintains systemic physiological homeostasis.
  • Dysregulation within kinin-mediated pathways contributes to cardiovascular pathology and blood pressure abnormalities.

Cite This Study

A 1995 study studied this question.

synapsesocial.com/papers/6a8d1b199a08a4eedd7fe626https://doi.org/10.1161/01.hyp.26.2.221
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abnormal regulation of renal kallikrein in experimental diabetes. Effects of insulin on prokallikrein synthesis and activation.1987 · 60 citations
  2. 2B<sub>1</sub>and B<sub>2</sub>Bradykinin Receptors Encoded by Distinct mRNAs1994 · 33 citations