Population
Explanted whole rat embryos at Day 10 1/2 (10-15 somites) or Day 11 (21-26 somites) of gestation
Design
Preclinical
Authors
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Animal data suggest sequential receptor maturation in embryos; leaves open translational relevance to human fetal cardiology.
This study demonstrates that functional muscarinic cholinergic receptors appear in the preinnervated rat embryo heart shortly after adrenergic receptors.
Robkin et al. (1976) studied this question.
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