Why the study?
Vascular toxicity and thrombotic events related to gemcitabine seem to be underreported.
Population
2 patients with advanced cancers receiving gemcitabine-based chemotherapy
Design
Case report
Authors
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Prompts vigilance for severe digital ischemia during gemcitabine therapy, particularly with preexisting peripheral arterial disease.
Gemcitabine can cause severe digital ischemic events, highlighting the need for caution in patients with preexisting peripheral arterial disease or evolving Raynaud's phenomenon.
Fabien et al. (2023) studied this question.
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