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August 25, 2026

The anterior subcutaneous WAT has greater beiging potential than the inguinal WAT in mice.

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Why the study?

White adipose tissue beiging is important for metabolic health, but depots exhibit substantial functional heterogeneity across anatomical locations.

Population

Mice

Comparison

asWAT vs iWAT under thermoneutral (25 °C) and cold-exposure (4 °C) conditions

Key result

Anterior subcutaneous white adipose tissue exhibited a more pronounced beige-like phenotype and greater thermogenic capacity compared to inguinal subcutaneous white adipose tissue in mice.

Authors

JCJingwen CaiXZXinzhi ZhangLSLingyu Sun

Discussion

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Overview

Depot-specific beiging differences in mice extend WAT heterogeneity data; leaves open human metabolic translation.

Key Points

  • To compare the beiging capacity and thermogenic potential of anterior subcutaneous white adipose tissue against inguinal subcutaneous white adipose tissue in mice across different temperatures.
  • Assessed anterior subcutaneous white adipose tissue (asWAT) and inguinal subcutaneous white adipose tissue (iWAT) in mice exposed to thermoneutral (25 °C) and cold (4 °C) conditions.
  • Performed histomorphological evaluation, RNA sequencing, RT-qPCR, Western blotting, immunofluorescence staining, and mitochondrial DNA copy-number quantification.
  • asWAT exhibited a more prominent beige-like phenotype compared with iWAT under both thermoneutral and cold conditions, marked by smaller adipocyte size and elevated expression of thermogenic genes.
  • Transcriptomic and molecular analyses showed significant upregulation of oxidative phosphorylation pathways, enhanced mitochondrial abundance, and increased thermogenic activity in asWAT relative to iWAT.

PICO

P
Population
Mice evaluated for beiging potential of anterior subcutaneous WAT versus inguinal subcutaneous WAT under thermoneutral and cold-exposure conditions.
E
Exposure / Comparator
Anterior subcutaneous WAT (asWAT) vs Inguinal subcutaneous WAT (iWAT)
O
Primary Outcome
Beiging potential (adipocyte size, thermogenic gene expression, mitochondrial abundance and activity)

Cite This Study

Cai et al. (2026) studied this question. Anterior subcutaneous WAT (asWAT) vs. Inguinal subcutaneous WAT (iWAT) was evaluated on Beiging potential (adipocyte size, thermogenic gene expression, mitochondrial abundance and activity). Anterior subcutaneous white adipose tissue exhibited a more pronounced beige-like phenotype and greater thermogenic capacity compared to inguinal subcutaneous white adipose tissue in mice.

synapsesocial.com/papers/6a8d4a34e8bd2413309bc299https://doi.org/10.1159/cto/acbag002
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