Key result
Advancing age was significantly associated with increased alpha-1-acid glycoprotein concentration (r = 0.28; P<0.02), but had no relationship with the percentage of unbound imipramine.
Why the study?
Does age affect alpha-1-acid glycoprotein concentration and imipramine plasma protein binding in subjects without overt clinical illness?
Population
69 subjects, aged 20-97 years, with no evidence of acute or chronic inflammatory disease or malignancy, and…
Design
Cross-sectional
Authors
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Supports unchanged imipramine binding despite age-related AAG rise in healthy elderly; leaves open effects during acute illness.
Cohort (n=69)
Does age affect alpha-1-acid glycoprotein concentration and imipramine plasma protein binding in subjects without overt clinical illness?
Effect estimate: r = 0.28
p-value: p=<0.02
Although alpha-1-acid glycoprotein concentration increases with age, it does not cause a clinically significant change in the protein binding of drugs like imipramine in the absence of overt clinical illness.
Lawrence J. Kerzner (1984) reported a cohort. Advancing age was evaluated on Alpha-1-acid glycoprotein concentration (r = 0.28, p=<0.02). Advancing age was significantly associated with increased alpha-1-acid glycoprotein concentration (r = 0.28; P<0.02), but had no relationship with the percentage of unbound imipramine.