Gender, but not age, significantly affects serum alpha 1-acid glycoprotein concentration, though it does not change the protein binding of disopyramide in healthy subjects.
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Gender differences in AAG do not alter disopyramide binding in healthy subjects; leaves open relevance in disease or for other drugs.
Age- and gender-related changes in serum alpha 1-acid glycoprotein (AAG) concentration and the serum protein binding of disopyramide were examined after intensive medical examination. Based on the clinical chemistry tests over 51 points, 245 subjects were diagnosed as healthy and 71 subjects (22.5%) revealed an abnormal value for at least one item. In the healthy subjects, serum AAG concentration in men was significantly higher than in women (men, 0.78 +/- 0.18 mg/mL, mean +/- SD; women, 0.67 +/- 0.16 mg/mL). In contrast, there were no significant differences in the AAG concentration between age groups for men and women and in the unbound fraction of disopyramide. Gender changes AAG concentration. Age, however, does not change AAG concentration and the protein binding of the basic drug.
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Kishino et al. (1995) studied this question.
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