Population
5 healthy male Japanese volunteers, age 21-24 years, mean weight 59.2 kg.
Design
Other
Follow-up
7 hours for oral administration, 4 hours for intravenous…
Authors
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Supports comparable disopyramide dosing in Japanese patients; leaves open need for larger prospective validation before practice change.
The pharmacokinetics of disopyramide in Japanese subjects are comparable to those reported in other populations, with a 2-compartment model best describing its intravenous disposition.
Kusuoka et al. (1980) studied this question.
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