Why the study?
Do different commercial preparations of oral disopyramide differ in their bioavailability and pharmacokinetic profiles in volunteers?
Population
8 volunteers
Comparison
Disopyramide administered intravenously and… vs Comparison between intravenous administration…
Design
Other
Authors
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Minor disopyramide formulation differences lack clinical significance; leaves open confirmation in patient outcome studies.
Do different commercial preparations of oral disopyramide differ in their bioavailability and pharmacokinetic profiles in volunteers?
While there are statistically significant differences in bioavailability between two oral formulations of disopyramide, the 5-15% difference is unlikely to be clinically meaningful.
Bryson et al. (1978) studied this question.
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