Why the study?
What is the relationship between plasma concentration of disopyramide and QT prolongation in healthy subjects?
Population
8 healthy subjects
Design
Other
Authors
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Confirms consistent concentration-QT relationship for disopyramide in healthy subjects; leaves open translation to patients.
What is the relationship between plasma concentration of disopyramide and QT prolongation in healthy subjects?
A combined pharmacokinetic-pharmacodynamic model demonstrates a consistent relationship between disopyramide plasma concentration and QT prolongation regardless of administration route.
Whiting et al. (1980) studied this question.
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