Why the study?
What are the pharmacokinetic properties of disopyramide in patients recovering from myocardial infarction?
Population
9 patients with ischaemic heart disease recovering from myocardial infarction
Design
Cohort
Authors
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May guide disopyramide dosing post-MI; leaves open prospective validation before practice change.
What are the pharmacokinetic properties of disopyramide in patients recovering from myocardial infarction?
In patients recovering from MI with normal renal function, a standard loading dose of 2 mg/kg of disopyramide followed by maintenance dosing 3-4 times daily is appropriate due to reduced volume of distribution and clearance.
Bryson et al. (1982) studied this question.
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