Key result
Fenoldopam exerts DA-1 agonist and antagonist effects, and its antagonist property along with renin-angiotensin system activation appears responsible for tolerance to its hypotensive effects in rats.
Population
Pentobarbital-anesthetized rats, conscious spontaneously hypertensive rats, and normotensive…
Comparison
Intravenous infusions of fenoldopam vs Pretreatment with enalapril, pepstatine…
Design
Preclinical
Follow-up
15 min
Authors
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Suggests caution with prolonged fenoldopam use; leaves open DA-1 modulation as a research target in hypertension.
Tolerance to the hypotensive effects of fenoldopam in rats is driven by renin-angiotensin system activation and DA-1 antagonist effects, except in the renal vascular bed.
Lefèvre-Borg et al. (1988) studied this question. Fenoldopam was evaluated on Hypotensive effects and tolerance (blood pressure, vascular resistance). Fenoldopam exerts DA-1 agonist and antagonist effects, and its antagonist property along with renin-angiotensin system activation appears responsible for tolerance to its hypotensive effects in rats.
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