Key result
There is no solid evidence to support using ACE inhibitors or ARBs as antiarrhythmic therapy in patients with atrial fibrillation, though they may be beneficial for those with other indications.
Why the study?
Do ACE inhibitors or ARBs prevent the occurrence or recurrence of atrial fibrillation?
Do ACE inhibitors or ARBs prevent the occurrence or recurrence of atrial fibrillation?
ACE inhibitors and ARBs lack solid evidence as primary antiarrhythmic therapy for atrial fibrillation, but may be useful in patients with recurrent AF who have other indications for RAS blockade.
ACEi/ARBs lack support as antiarrhythmic therapy in AF; leaves open benefit when other indications for RAS blockade exist.
OBJECTIVE: The objective of the study was to review the current available clinical evidence for the role of renin-angiotensin system (RAS) blockade in the treatment of atrial fibrillation (AF). METHOD: We conducted a Pubmed and Medline literature search (January 1980 through May 2007) to identify all clinical trials published in English involving the use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) for preventing the occurrence or recurrence of AF. Discussing pathophysiology and experimental evidence in detail is beyond the scope of this article. CONCLUSION: There is no solid evidence to support using ACE inhibitors or ARBs as antiarrhythmic therapy in patients with AF. However, in view of the possible benefits and the low incidence of side effects with ACE inhibitors and ARBs, they might be given in patients with recurrent AF, particularly if there are other indications for their use such as hypertension, HF, or diabetes mellitus. Possible benefits from pre-treatment argue in favour of using ACE inhibitors and ARB as first-line therapy in patients with hypertension.
No takes yet. Share an insight, caveat, or question.
Soran et al. (2008) conducted a review in Atrial fibrillation. ACE inhibitors or ARBs was evaluated on Occurrence or recurrence of atrial fibrillation. There is no solid evidence to support using ACE inhibitors or ARBs as antiarrhythmic therapy in patients with atrial fibrillation, though they may be beneficial for those with other indications.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: