Key result
In patients with diabetic and alcoholic polyneuropathies, there was a significant negative correlation between the current perception threshold to 5 Hz stimulation and the amplitude of sympathetic skin response.
Cross-Sectional (n=48)
No
Current perception threshold to 5 Hz stimulation and sympathetic skin response are concurrently impaired in diabetic and alcoholic polyneuropathies, reflecting C fiber dysfunction.
Answers are grounded in this paper and cite their sources.
Association suggests concurrent C-fiber impairment in these polyneuropathies; hypothesis-generating and requires prospective validation before clinical use.
OBJECTIVE: Correlation between current perception threshold and sympathetic skin response was investigated in patients with diabetic or alcoholic polyneuropathy. METHODS: Current perception threshold was measured using Neurometer CPT/C, and the sympathetic skin response was measured using Neuropack sigma. PATIENTS: Fourteen patients with diabetic polyneuropathy and 10 patients with alcoholic polyneuropathy were studied. RESULTS: There was a significant negative correlation between the current perception threshold to 5 Hz stimulation and the amplitude of sympathetic skin response. CONCLUSION: Since both current perception threshold to 5 Hz stimulation and sympathetic skin response are related to C fibers, these two are considered to be impaired concurrently in diabetic and alcoholic polyneuropathies.
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Oishi et al. (2002) conducted a cross-sectional in Diabetic and Alcoholic Polyneuropathy (n=48). Diabetic or alcoholic polyneuropathy vs. Healthy controls was evaluated on Correlation between current perception threshold to 5 Hz stimulation and amplitude of sympathetic skin response (r = -0.58 to -0.69, p=<0.01). In patients with diabetic and alcoholic polyneuropathies, there was a significant negative correlation between the current perception threshold to 5 Hz stimulation and the amplitude of sympathetic skin response.
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