Key result
Amlodipine (10 mg), captopril (12.5 mg), and their half-dose combination demonstrated comparable efficacy in achieving target blood pressure reduction in patients with hypertensive urgency.
Why the study?
Does amlodipine, captopril, or their combination improve efficacy and safety in patients with hypertensive urgency at the emergency room?
RCT (n=82)
Double-blind
Permuted block design with random block sizes of 3, 6, and 9
No
Does amlodipine, captopril, or their combination improve efficacy and safety in patients with hypertensive urgency at the emergency room?
Supports any of the three regimens for hypertensive urgency; confirms comparable efficacy in this RCT.
Objective: To compare the efficacy and safety of 10 mg amlodipine, 12.5 mg captopril and combination of 5 mg amlodipine and 6.25 mg captopril in patients with hypertensive urgency at emergency room.
No takes yet. Share an insight, caveat, or question.
Kotruchin et al. (2016) conducted an RCT in Hypertensive urgency (n=82). Amlodipine, Captopril, or their combination vs. Active comparators (each other) was evaluated on 15% to 25% reduction in mean arterial blood pressure (MAP). Amlodipine (10 mg), captopril (12.5 mg), and their half-dose combination demonstrated comparable efficacy in achieving target blood pressure reduction in patients with hypertensive urgency.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: